Article Index

Genomics

Researchers continue to look at the genomics of ME/CFS. Ekua Brenu (PhD candidate from Bond University AU) examined microRNAs (miRNAs) that modulate gene expression in PWCs, particularly those that modulate CD8 cells and Natural Killer cells. Both of these subsets are reduced in ME/CFS. She studied 30 PWCs and compared results from 30 healthy controls. Of the 15 miRNAs studied, six were down-regulated in ME/CFS compared to controls, substantiating that miRNAs may be responsible for poor function of these cells in ME/CFS.

One of the most enlightening studies of the meeting was performed by Drs. Alan and Kathleen Light, and presented by Dr. Cindy Bateman. The Lights compared the gene expression response to exercise in 48 PWCS (15 had CFS only, 33 had CFS+FM) to 49 controls, 20 persons with Multiple Sclerosis, and 18 persons with FM only. Subjects rode an Airdyne bicycle for 25 minutes at 70% of their maximum predicted heart rate, and mRNA was measured at 30 minutes, 8, 24, and 48 hours after exertion.

Patterns of gene expression were remarkably different in each group. Of patients with CFS only there was a subset of 5 / 15 who showed a notable reduction in Ad2A, or α-adrenergic receptors. Of these, 71% had orthostatic intolerance such as Neurally Mediated Hypotension or Postural Orthostatic Tachycardia Syndrome. In addition, gene expression patterns were able to distinguish:
o    likelihood of orthostatic intolerance
o    FM versus ME/CFS
o    FM only from Major Depressive Disorder, and
o    the severity of ME/CFS
[Ed. note:  This technology shows real promise as a marker for persons with ME/CFS or FM. ]