Evidence for CNS involvement in CFS

"...substantial objective evidence of abnormalities in the Central Nervous System (CNS) is now available. Magnetic resonance imaging has revealed punctuate areas of high signal in the white matter more often in patients with CFS than in healthy control subjects."

"[SPECT scan] abnormalities are formed more of­ten in patients with CFS than in...patients with de­pression."

"Hypothalamic functional testing is abnormal in many patients with CFS. In addition to the hypofunction of corticotropin-releasing hormone neurons in the hypothalamus mentioned earlier, disruption of both serotonergic and noradrenergic pathways has been demonstrated in patients with CFS. Typically, these abnormalities are in patterns opposite to those seen in depression..."