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Home Resource Library Research Dr. Natelson's preliminary findings of protein changes in the spinal fluid of CFIDS patients
Dr. Natelson's preliminary findings of protein changes in the spinal fluid of CFIDS patients PDF Print E-mail

June 2005

Dr. Benjamin Natelson, M.D., professor of neurosciences at the University of New Jersey Medical School, is a highly respected Chronic Fatigue Syndrome/Chronic Fatigue and Immune Dysfunction Syndrome/Myalgic Encephalopathy (CFS/CFIDS/ME) researcher. He recently, using a new technology called proteomic profiling, has found abnormal proteins in the spinal fluid of CFS/CFIDS/ME patients.

The purpose of his research is to seek possible causes and diagnostic markers for CFS/CFIDS/ME.

In the early stages of this research, he has already found at least 5 "CFS-related alterations... in both the high and low molecular weight ranges." One of the proteins "that is present in all healthy controls... appears absent or reduced in 81% of CFIDS patients." Dr. Natelson, in the next phase of his research, is seeking to identify this protein. Likely candidates are a thryroid hormone transport protein and a brain-derived neurotrophic factor. The protein alterations could explain various CFS/CFIDS/ME symptoms, including exhaustion, cognition and memory problems, and neural aberrations.

Dr. Natelson wishes to continue and broaden his research to test the spinal fluids of more CFS/CFIDS/ME patients and controls to determine if a CFIDS-specific altered protein profile exists and if such a profile can be used as a diagnostic marker.

Although his work is in its early stages, it seems like a valuable line of research since the spinal fluid may provide access to determining organic changes in the brain.

 
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